Final answer:
Tricyclic Antidepressants (TCAs) block the reuptake of various neurotransmitters including monoamine, and are less commonly used today due to their significant side effects and overdose risk, in contrast to SSRIs which are more selective and generally safer.
Step-by-step explanation:
The drug that blocks the reuptake of monoamine, histamine, acetylcholine, and alpha-2 adrenergic receptors is commonly known as a Tricyclic Antidepressant (TCA). TCAs are known for their ability to inhibit reuptake of neurotransmitters, particularly epinephrine, and serotonin. While effective, they have fallen out of favor compared to newer medications due to their side effects and potential for fatal overdose. In contrast, Selective Serotonin Reuptake Inhibitors (SSRIs) mostly inhibit the reuptake of serotonin alone, leading to higher levels of serotonin in the central nervous system with fewer side effects.