32.9k views
2 votes
Chemotherapy Agents: Administering Doxorubicin (Active Learning Template - Medication, RM Pharm RN 7.0 Chp 42)

1 Answer

0 votes

Final answer:

Doxorubicin is an anthracycline chemotherapy agent used for treating solid tumors by intercalating with DNA and inhibiting topoisomerase II, leading to DNA strand breakage. It can be administered intravenously and is part of various drug combinations including doxorubicin with cyclophosphamide. Targeted chemotherapy is a sophisticated form of treatment that aims to minimize side effects.

Step-by-step explanation:

Doxorubicin, a chemotherapy agent from the anthracycline group, is extensively used for the treatment of various solid tumors. As a chemotherapeutic medication, its primary mechanism is to intercalate with DNA, affecting vital processes such as DNA and RNA synthesis. It also causes DNA strand breakage through the inhibition of topoisomerase II. Some commonly used chemotherapeutic combinations include doxorubicin with cyclophosphamide, and in some cases, alongside vincristine and prednisolone. While effective in cancer treatment, doxorubicin can also be delivered as part of a more sophisticated approach known as targeted chemotherapy, which aims to reduce adverse side effects by focusing on particular molecules that are more prevalent in cancerous cells.

As with other chemotherapy agents, doxorubicin is often given intravenously to ensure direct delivery into the bloodstream. This method not only facilitates a faster response but also enhances the efficiency of the drug. Due to its potency and associated toxic effects, patients undergoing treatment with doxorubicin require diligent monitoring by healthcare professionals.

User Andy Meissner
by
8.3k points