Question

Which of the following best explains why a bone marrow transplant may not be appropriate from a given donor to a given recipient even though they are compatible for blood transfusions?

A Engraftment can be delayed because of infection, medicines, low donated stem cell count, or graft failure.
B Their blood-types may match but major histocompatibility (MHC) proteins may not be a matching
C The closer the HLA match, the better chance that a bone marrow transplant will succeed.
D After your transplant, your own immune cells might react to your donor's cells and start to attack them because they see them as different.

Answer 1

Bone marrow transplants may not be appropriate between compatible blood transfusion donors and recipients due to mismatched major histocompatibility (MHC) proteins. The closer the HLA match, the better chance of success in a bone marrow transplant. If the match is not good, rejection or graft-versus-host disease may occur.

Step-by-step explanation:

A bone marrow transplant may not be appropriate from a given donor to a given recipient even though they are compatible for blood transfusions due to the major histocompatibility (MHC) proteins not being a matching. While their blood types may match, the MHC proteins play a crucial role in determining the likelihood of rejection. The closer the HLA match, the better chance that a bone marrow transplant will succeed. If the match is not good, the patient's body could reject the transplant or experience graft-versus-host disease, where the transplanted bone marrow attacks the recipient's body.