Final answer:
Amide and ester-type anesthetics differ in the stability of the linkage between their hydrophilic and hydrophobic domains. Ester-type anesthetics have a readily hydrolyzable bond, while amide-type anesthetics have a more stable bond. Changes in the molecule can impact the potency and toxicity of the anesthetic.
Step-by-step explanation:
When talking about anesthetics, the amide and ester types refer to the linkage between the hydrophilic and hydrophobic domains in the structures.
The ester link is easily hydrolyzed in the body, while the amide link is more stable.
An example of an ester-type anesthetic is procaine, and an example of an amide-type anesthetic is lidocaine.
Changes in the molecule can affect the potency and toxicity of the anesthetic.