Final answer:
Edema is the disease that results in fluid accumulation in interstitial spaces. It is characterized by swelling, increased size of the affected area, and stretched, tight skin. Pressing a finger into the suspected area can determine if the edema is 'pitting.'
Step-by-step explanation:
The disease that results in fluid accumulation in interstitial spaces is called edema. Edema is the accumulation of excess water in the tissues, particularly in the soft tissues of the extremities. There are various physiological causes of edema, including water leakage from blood capillaries. Common symptoms of edema include swelling, increased size of the affected area, and stretched, tight skin. Edema is often associated with circulatory deficits and can be checked by pressing a finger into the suspected area to see if a depression persists after it is removed, which is called 'pitting.'