Final answer:
The first heart sound, known as S1 or "lub," indicates the closure of the atrioventricular valves during the transition to ventricular systole.
Step-by-step explanation:
When auscultating a patient's heart sounds, the first sound of the cardiac cycle, known as S1 or the "lub" sound, indicates the closure of the atrioventricular valves during ventricular systole. This sound occurs when the ventricles begin to contract, causing ventricular pressure to rise above the pressure in the atria, which in turn leads to the closing of the tricuspid and mitral valves. This phase is known as isovolumic or isovolumetric contraction and marks the transition from diastole to ventricular systole.