Final answer:
The parenteral route of medication administration may place the patient at a higher risk of reactions.
Step-by-step explanation:
The parenteral route of medication administration refers to the injection of a drug directly into the body, bypassing the gastrointestinal tract. A true statement regarding a disadvantage of the parenteral route is option 4: The parenteral route may place the patient at a higher risk of reactions. This is because injecting a drug directly into the bloodstream can lead to a faster and sometimes more intense drug response compared to other routes of administration, increasing the risk of side effects or adverse reactions.