Final answer:
Osteoporosis most likely requires a decrease in exposure factors during radiographic imaging due to its characteristic of reduced bone density, which leads to skeletal weakness.
Step-by-step explanation:
The pathologic condition that would most likely require a decrease in exposure factors for radiographic imaging is Osteoporosis. Osteoporosis is characterized by a decrease in bone density, which results in skeletal weakness. The reduced bone mass means that less radiation is needed to penetrate the bones for clear imaging compared to normal or denser bone. Conversely, conditions like Osteosclerosis would likely require an increase in exposure due to denser bone mass.