Final answer:
In sickle cell anemia, as oxygen is released, erythrocytes take on a sickle shape due to the abnormal hemoglobin S, which can cause blockages and various health complications.
Step-by-step explanation:
As oxygen is released from erythrocytes in sickle cell anemia, the red blood cells assume a characteristic sickle shape or crescent shape. This change is due to the abnormal hemoglobin S (HbS) produced by the erythrocytes, which causes the cells to become elongated and rigid, impairing their ability to deliver oxygen and pass through small capillaries. The sickle-shaped cells can lead to blockages in blood flow, causing various complications such as pain, organ damage, and increased risk of infections.