Final answer:
Bisphosphonates have been associated with osteonecrosis of the jaw following dental procedures that traumatize the jaw bone.
Step-by-step explanation:
Osteonecrosis of the jaw following tooth extraction or other dental procedures that traumatize the jaw bone has been associated with the use of bisphosphonates in the treatment of osteoporosis. Bisphosphonates, which decrease the activity of osteoclasts, are often prescribed to slow down bone loss. However, in a small percentage of cases, bisphosphonates themselves have been linked to an increased risk of osteonecrosis of the jaw. This risk is specifically associated with dental procedures that cause trauma to the jaw bone.