Final answer:
In a child with Von Willebrand's disease, guarding against bleeding injuries is the priority nursing intervention to prevent complications related to their bleeding disorder.
Step-by-step explanation:
The priority nursing intervention that should be included in the plan of care for a hospitalized child with Von Willebrand's disease is guarding against bleeding injuries. Since Von Willebrand's disease is a bleeding disorder characterized by a deficiency of Von Willebrand factor, which is important for platelet adhesion, patients are at an increased risk of bleeding. Therefore, it is crucial for nurses to take steps to prevent injuries that could lead to bleeding complications.