Final answer:
Carpal Tunnel Syndrome is a condition resulting from the compression of the median nerve in the wrist, causing pain and tingling in the thumb and first three fingers.
Step-by-step explanation:
Pain and tingling in the thumb and first three fingers of the hand are commonly associated with Carpal Tunnel Syndrome, which is a condition where the median nerve becomes compressed in the wrist. This compression can lead to symptoms such as pain, numbness, and tingling, specifically in the thumb, index, middle, and part of the ring finger. While nonsurgical treatments like wrist splints and corticosteroid injections can provide temporary relief, surgery to cut the carpal ligament may offer more definitive relief by reducing pressure on the median nerve.