Final answer:
After 5-10 years of taking Carbidopa/Levodopa for Parkinson’s disease, patients may experience reduced effectiveness of the medication, causing motor fluctuations and involuntary writhing movements known as dyskinesias.
Step-by-step explanation:
When a person has been taking Carbidopa/Levodopa for 5-10 years to manage symptoms of Parkinson’s disease, several long-term effects can occur. These medications are intended to reduce motor disturbances by replacing dopamine, a neurotransmitter that becomes deficient in patients with Parkinson's. However, over time, the effectiveness of these medications can diminish and patients may experience motor fluctuations and dyskinesias, which are involuntary writhing movements. The underlying pathogenesis involving the buildup of Lewy bodies continues to damage neurons, causing a progression of symptoms despite medication.
It’s essential for patients and physicians to work closely to manage these long-term effects. Medication regimens might be adjusted, additional therapies may be considered, and supportive care becomes increasingly important as the disease advances.