Final answer:
Ezetimibe is metabolized in the liver primarily through glucuronidation and excreted in the bile. It is important to note that ezetimibe is primarily metabolized by enzymes in the liver. Ezetimibe is a lipid-lowering medication that reduces cholesterol absorption in the intestine.
Step-by-step explanation:
Ezetimibe is metabolized in the liver primarily through glucuronidation, a process where it is conjugated with glucuronic acid to form ezetimibe glucuronide.
This metabolite is then excreted primarily in the bile and eliminated in feces. Only a small percentage of ezetimibe is excreted unchanged in the urine.
It is important to note that ezetimibe is primarily metabolized by enzymes in the liver, specifically UDP-glucuronosyltransferases (UGTs).
Ezetimibe is widely used as a lipid-lowering medication to reduce cholesterol absorption. By inhibiting the Niemann-Pick C1-Like 1 (NPC1L1) protein, which is responsible for cholesterol absorption in the intestine, ezetimibe reduces the amount of cholesterol that enters the bloodstream.