Final answer:
The best medication combination for long-term control of asthma, when monotherapy with SABA is insufficient, is SABA + LABA + ICS. This combination addresses both immediate bronchodilation and chronic inflammation providing optimal asthma control.
Step-by-step explanation:
For a patient with asthma who is no longer well controlled with monotherapy using a Short-Acting Beta Agonist (SABA), the next step for long-term control typically involves adding a Long-Acting Beta Agonist (LABA) and an Inhaled Corticosteroid (ICS). This combination aims to provide both immediate relaxation of constricted airways and long-term reduction of inflammation in the lungs. Therefore, the best combination of medications for long-term control of asthma, from the options provided, would be SABA + LABA + ICS.
Inhaled corticosteroids are generally considered the most effective long-term treatment for controlling chronic inflammation in asthma. Complementing ICS with LABA optimizes control over asthma symptoms by preventing airway constriction over a more extended period. However, it is essential to be monitored by a healthcare professional, as these medications must be correctly dosed and adjustments made based on the patient's response and changes in symptoms.