Question

A 70 year old female patient has been diagnosed with active TB infection. She has a history of retinal vein occlusion, arthritis, and stomach ulcer. What medication should be avoided in this patient?

a. INH
b. Rifampin
c. Ethambutol
d. Pyrazinamide

Answer 1

The medication to be avoided in the patient with active TB infection, retinal vein occlusion, arthritis, and stomach ulcer is Pyrazinamide due to potential exacerbation of arthritis and stomach ulcer complications.

Step-by-step explanation:

In this case, the medication that should be avoided in a 70-year-old female patient with active TB infection, retinal vein occlusion, arthritis, and stomach ulcer is Pyrazinamide. Pyrazinamide is known for its potential to increase uric acid levels and can lead to hyperuricemia, which may exacerbate the patient's arthritis. Moreover, it can be hepatotoxic and might be harsh on a patient with a history of stomach ulcer. Isoniazid (INH), while having the potential for hepatotoxicity and neurotoxicity, would typically not be contraindicated based on the patient's history provided. Rifampin and Ethambutol do not specifically interact with the conditions mentioned. When treating TB, it's crucial to consider the patient's existing comorbidities and the side effect profile of the medications.