Final answer:
Azythromycin (Zpak) for 10 days is the most appropriate medication for a 52-year-old female patient with COPD presenting with symptoms of pneumonia.
Step-by-step explanation:
The most appropriate medication for a 52-year-old female patient with COPD who presents with symptoms of pneumonia, such as fever, purulent sputum, increased wheezing, and dyspnea, would be Azythromycin (Zpak) for 10 days.
Azythromycin is a macrolide antibiotic that is effective against bacterial respiratory infections, including pneumonia. It is commonly used when there is concern about resistance to ß-lactam antibiotics, such as penicillin. In addition, macrolides are also used for patients with COPD exacerbations.