Final answer:
The nurse practitioner should avoid prescribing Lisinopril due to its reduced efficacy as monotherapy in African American patients and increased risk of angioedema
Step-by-step explanation:
The nurse practitioner should avoid prescribing Lisinopril for a 66 year old African American female patient with a history of hypertension, diabetes, obesity, osteopenia, and allergies including sulfonylureas. Lisinopril is an ACE inhibitor and is less effective as monotherapy in African Americans compared to other ethnicities, and there is an increased risk of angioedema. Given the patient's allergy to sulfonylureas, which is a class of medications used to treat diabetes, caution must be exercised in managing both her hypertension and diabetes to minimize the risk of adverse reactions.