Final answer:
Full-thickness burns greater than 10% of the body require immediate referral to a burn center due to the severity of tissue and nerve damage.
Step-by-step explanation:
Full-thickness burns that cover more than a certain percentage of the body are a critical condition that require specialized care. According to medical guidelines, full-thickness burns greater than 10% of the body need immediate referral to a burn center. These are third-degree burns or worse, extending fully into the epidermis and dermis, destroying tissue, and affecting nerve endings. In the case of fourth-degree burns, muscle and bone are also affected. These severe burns necessitate medical interventions such as debridement (excision), possible amputation, and skin grafting.