Final answer:
The two growth factors that must be targeted by oral chemotherapy agents to have activity against renal cell carcinoma (RCC) are epidermal growth factor (EGF) and EGF receptor (EGFR).
Step-by-step explanation:
The two growth factors that must be targeted by oral chemotherapy agents to have activity against renal cell carcinoma (RCC) are epidermal growth factor (EGF) and EGF receptor (EGFR). Upon binding of EGF to EGFR, two proteins associated with the receptor called GRB2 and SOS are activated.
In RCC, the activation of EGFR plays a crucial role in the growth and progression of the cancer cells.