Final answer:
The best treatment option for a patient with an opaque, yellowed, and thickened nail with hyperkeratosis on the great toe is Terbinafine (Lamisil) taken orally (PO).
Step-by-step explanation:
The best treatment option for a patient with an opaque, yellowed, and thickened nail with hyperkeratosis on the great toe is terbinafine (Lamisil) taken orally (PO).
Cutaneous candidiasis, which can cause yellowed, thickened nails, is commonly treated with azole antifungal medications. Terbinafine is an allylamine antifungal drug that is effective against dermatophytic skin infections such as nail fungus. It can be taken orally for the treatment of nail fungus.
Other treatment options mentioned in the references include topical azole antifungal medications like Ciclopirox (Penlac), oral medications such as Doxycycline, and another topical antifungal called Efinaconazole (Jublia). However, the most suitable and effective option for this patient's condition is Terbinafine (Lamisil).