Final answer:
Quetiapine (Seroquel) may have a high risk of weight gain, unlike bupropion (Wellbutrin), metformin (Glucophage), and topiramate (Topamax), which are typically associated with weight loss or have no significant impact on weight.
Step-by-step explanation:
Among the medications listed, quetiapine (Seroquel) is known to have a high risk of weight gain. Quetiapine is an atypical antipsychotic used for treating conditions such as schizophrenia, bipolar disorder and depression. It is notorious for its metabolic side effects, which include weight gain, hyperglycemia and dyslipidemia.
On the contrary bupropion (Wellbutrin) is often associated with weight loss rather than gain and metformin (Glucophage) is typically used to lower glucose levels and can lead to weight loss as well. Furthermore topiramate (Topamax) is often prescribed for conditions like epilepsy and migraine prevention and is also associated with weight loss in many cases.