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A patient has recently been prescribed omeprazole (Prilosec) for GERD. He also takes lisinopril (Zestril). His PMH includes migraines, hypertension, and chronic kidney disease. The nurse practitioner notes:

a. The patient should stop taking the omeprazole (Prilosec) due his diagnosis of chronic kidney disease.
b. The patient should stop taking omeprazole (Prilosec) due to drug interaction with lisinopril (Zestril).
c. The patient may continue taking the omeprazole (Prilosec) but should monitor blood pressure.
d. The patient may continue taking omeprazole (Prilosec) as prescribed.

User Scott Yang
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1 Answer

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Final answer:

The patient may continue taking omeprazole for GERD while being monitored for their chronic kidney disease; there is no direct interaction with lisinopril.

Step-by-step explanation:

When considering the management of a patient who has been prescribed omeprazole (Prilosec) for GERD and is also taking lisinopril (Zestril) with a past medical history (PMH) that includes migraines, hypertension, and chronic kidney disease (CKD), it is important to assess potential drug interactions and contraindications. Omeprazole is a medication from the class of proton pump inhibitors (PPIs), which work by reducing the amount of acid produced in the stomach, thus relieving symptoms of GERD. Lisinopril, on the other hand, belongs to a class of medications known as angiotensin-converting enzyme (ACE) inhibitors, which are used to treat hypertension.

Research has shown that there could be a possible association between long-term use of PPIs, like omeprazole, and an increased risk of kidney problems. However, there is no direct contraindication or known harmful drug interaction between omeprazole and lisinopril that would require the discontinuation of omeprazole. Therefore, the patient may continue taking omeprazole as prescribed, but should be monitored periodically to assess renal function and ensure that CKD is not worsening.

The most suitable answer to the quiz question is d. The patient may continue taking omeprazole (Prilosec) as prescribed.

User Maribeth
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