Question

Goodpasture syndrome is:

1. Characterized by glomerulonephritis and pulmonary hemorrhage resulting from immune complex damage to the glomerular and alveolar basement membranes.
2. Characterized by massive proteinuria, hypoalbuminemia, hyperlipidemia, and edema.
3. An inflammatory autoimmune disorder affecting the connective tissue of the body, with inflammatory lesions involving the supportive tissues of the glomeruli.
4. Typically the end stage of other glomerular disorders, such as rapidly progressive glomerulonephritis, lupus nephritis, or diabetic nephropathy.

Answer 1

Goodpasture syndrome is an autoimmune condition characterized by glomerulonephritis and pulmonary hemorrhage due to immune complex damage to basement membranes in the lungs and kidneys.

Step-by-step explanation:

Goodpasture syndrome is characterized by a specific type of glomerulonephritis and pulmonary hemorrhage resulting from immune complex damage to the glomerular and alveolar basement membranes. This condition is an autoimmune disorder where the body's immune system mistakenly attacks its own tissues, specifically the kidneys and lungs. It is not the same as nephrotic syndrome, which involves massive proteinuria, hypoalbuminemia, hyperlipidemia, and edema, nor is it typically the end stage of other glomerular disorders.

Goodpasture syndrome is an example of an immune complex disease, which is also seen in other conditions such as rheumatoid arthritis and systemic lupus erythematosus. In this syndrome, the immune complexes that form can lodge in the capillary endothelial cell junctions triggering a damaging inflammatory response, which is why it shares some manifestations with other glomerulonephritic conditions.

Therefore, the correct characterization of Goodpasture syndrome aligns with the first option, highlighting the syndrome's immunological basis and its effects on the lungs and kidneys.