Question

You are referring a 73-year-old client for management of his prostate cancer with hormonal therapy. It is understood that goserelin acetate (Zoladex) acts as a method of androgen ablation by:

1. Blocking the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH).
2. Blocking 5-alpha-reductase, which converts testosterone into dihydrotestosterone.
3. Inhibiting the binding of testosterone to cancer cells.
4. Inhibiting the progression of cancer cells through the cell cycle.

Answer 1

Goserelin acetate (Zoladex) blocks the release of FSH and LH, reducing testosterone production and inhibiting the progression of prostate cancer cells.

Step-by-step explanation:

Goserelin acetate (Zoladex) acts as a method of androgen ablation by blocking the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH), which are responsible for stimulating testosterone production in the testes. By blocking the release of FSH and LH, goserelin acetate reduces the production of testosterone, effectively inhibiting the progression of prostate cancer cells. This hormonal therapy helps slow down the growth of the cancer and manage the symptoms of prostate cancer in older patients like your 73-year-old client.