Final answer:
It is true that a pharmacy must return their certificate of registration and any unused DEA 222 Forms to DEA Headquarters if they cease operations, either completely or just regarding controlled substances.
Step-by-step explanation:
The statement that a pharmacy must return their certificate of registration and any unused DEA 222 Forms to DEA Headquarters if they discontinue operations completely or in regards to controlled substances is True. The DEA 222 Forms are specifically used for tracking controlled substances. When a pharmacy closes or stops handling these substances, they have the responsibility to ensure that these forms are properly returned to prevent any potential misuse or diversion of controlled substances.