Final answer:
Hereditary spherocytosis is an autosomal dominant disease with the classic triad of anemia, jaundice, and splenomegaly, different from the autosomal recessive sickle cell anemia.
Step-by-step explanation:
Hereditary spherocytosis is an autosomal dominant (AD) disease that presents with the classic triad of anemia, jaundice, and splenomegaly. Unlike sickle cell anemia, which is an autosomal recessive disorder and characterized by erythrocytes taking on a sickle or crescent shape, hereditary spherocytosis involves a defect in the red blood cell's cytoskeleton, leading to sphere-shaped erythrocytes. These spherocytes are less flexible and more prone to getting trapped in the spleen, causing the described symptoms. There is a difference in the pattern of inheritance and clinical manifestations between these two genetic conditions.