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Acute Myeloblastic Leukemia (AML), what cells are diagnostic?

User Jrturton
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In acute myelogenous leukemia (AML), there would be an expected impairment in the production of erythrocytes (red blood cells) since AML affects myeloid stem cells, which give rise to erythrocytes. Lymphocytes' production, which arises from the lymphoid stem cell line, is not directly impacted by AML. A bone marrow biopsy is the diagnostic test used for identifying abnormal cells indicative of AML.

Step-by-step explanation:

Acute Myeloblastic Leukemia (AML) Diagnostic Cells

Would you expect a patient with a form of cancer called acute myelogenous leukemia to experience impaired production of erythrocytes, or impaired production of lymphocytes? To answer this, it's important to understand the cell lineage affected in AML. Acute myeloblastic leukemia, also known as acute myelogenous leukemia, primarily involves an overproduction of immature leukocytes from the myeloid line. Specifically, AML impacts the myeloblast lineage of cells, which give rise to certain forms of granular leukocytes, such as neutrophils, eosinophils, and basophils, as well as monocytes.

Since AML affects the myeloid stem cells, we would expect that a patient may experience impaired production of other elements derived from myeloid stem cells, such as erythrocytes and megakaryocytes that produce platelets. Thus, the patient with acute myelogenous leukemia will likely have issues with the production of erythrocytes, which are crucial for carrying oxygen to tissues, leading to symptoms like fatigue. In contrast, the production of lymphocytes, which arise from the lymphoid stem cell line, is not directly impacted by AML.

In a diagnostic setting, a bone marrow biopsy is typically performed to identify the presence of abnormal myeloblasts in the bone marrow, confirming the diagnosis of AML. The bone marrow produces all the formed elements—erythrocytes, leukocytes, and platelets—and examining a sample of this red bone marrow is crucial for diagnosis.

User Micheal
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