Final answer:
Fourth-generation cephalosporins have a broad spectrum of activity and are effective against both gram-positive and gram-negative bacteria.
Step-by-step explanation:
Fourth-generation cephalosporins have a broad spectrum of activity and are effective against both gram-positive and gram-negative bacteria. They are especially useful in treating serious infections caused by multidrug-resistant organisms, including extended-spectrum beta-lactamase (ESBL)-producing bacteria. Examples of fourth-generation cephalosporins include cefepime and cefpirome. These antibiotics have an increased resistance to beta-lactamases, making them more effective against resistant strains of bacteria.