Final answer:
The contraindications to tPA therapy can be remembered using the acronym "SAMPLE STaGES".
Step-by-step explanation:
The contraindications to tPA therapy can be remembered using the acronym "SAMPLE STaGES". Each letter represents a different contraindication:
- Surgery or significant trauma within the past 2 weeks
- Active bleeding or known bleeding diathesis
- Malignant intracranial neoplasm (such as brain tumor)
- Persistent high blood pressure (systolic >185 mm Hg or diastolic >110 mm Hg)
- Large intracranial hemorrhage on head CT or MRI scan
- Endocarditis or other evidence of infection in the blood
- Severe liver disease
- Traumatic or prolonged CPR (>10 minutes)
- aNeurysm, arteriovenous malformation, or other intracranial structural abnormality
- Gastrointestinal or genitourinary bleeding within the past 21 days
- Evidence of recent active internal bleeding
- Stroke or severe head trauma within the past 3 months