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What antibodies are associated with polymyositis and dermatomyositis?

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Final answer:

Polymyositis is associated with anti-Jo-1 antibodies, while dermatomyositis is associated with anti-Mi-2 antibodies.

Step-by-step explanation:

Polymyositis and dermatomyositis are both autoimmune diseases that result in muscle inflammation. In polymyositis, the antibodies associated with the condition are known as anti-Jo-1 antibodies. These antibodies target an enzyme called histidyl-tRNA synthetase, which plays a role in protein synthesis. In dermatomyositis, the antibodies most commonly associated with the condition are anti-Mi-2 antibodies. These antibodies target a protein called Mi-2, which is involved in gene regulation and chromatin remodeling.

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