Question

Rb gene mutation, Paget Disease, and Teriparatide (PTH analog) administration all can increase the risk of which primary bone malignancy?

Answer 1

Rb gene mutation, Paget Disease, and Teriparatide administration increase the risk of osteosarcoma, a primary bone malignancy.

Step-by-step explanation:

Paget's disease is a disorder of the bone remodeling process that leads to weak and brittle bones. It is caused by overactive osteoclasts which resorb more bone than is laid down. It is diagnosed through imaging studies and lab tests, such as X-rays and bone scans. Blood levels of alkaline phosphatase are typically elevated in people with Paget's disease.

Rb gene mutation, Paget's disease, and administration of the PTH analog Teriparatide all increase the risk of osteosarcoma, which is a primary bone malignancy. Osteosarcoma is a type of bone cancer that forms in the cells that produce bone, and it can spread to other parts of the body.