Final answer:
A new pharmacy permit must be issued when there is a substantial change in ownership or controlling interest of the pharmacy, which is defined by specific state regulations.
Step-by-step explanation:
When considering change in ownership, a new pharmacy permit should be issued whenever there is a substantial change in the controlling interest or when a majority of ownership in the pharmacy is transferred to new owners. The definition of what constitutes a substantial change can vary by jurisdiction, so it's important to consult the relevant state's pharmacy board or regulatory body for specific guidance. Typically, the process involves submitting an application to the regulatory authority with required documentation, which may include background checks, ownership information, and proof of a qualified pharmacist in charge. Failure to obtain a new permit under these circumstances may lead to fines, sanctions, or the closure of the pharmacy.