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What is the MOA for both Propythiouracil (PTU) & Methimazole (Tapazole)?

User Rob Cannon
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Final answer:

Propythiouracil (PTU) and Methimazole (Tapazole) both work by inhibiting the enzyme thyroperoxidase, reducing the production of thyroid hormones to treat hyperthyroidism.

Step-by-step explanation:

The mechanism of action (MOA) for both Propythiouracil (PTU) and Methimazole (Tapazole) is inhibition of the enzyme thyroperoxidase, which is involved in the synthesis of thyroid hormones.

These medications are used in the treatment of hyperthyroidism, a condition characterized by an overactive thyroid gland that produces excessive amounts of thyroid hormones.

By inhibiting thyroperoxidase, PTU and Methimazole reduce the production of thyroid hormones, helping to normalize thyroid function in patients with hyperthyroidism.

User Uma Madhavi
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