Final answer:
ADRs for PTU include hepatotoxicity and vasculitis, while Methimazole can cause agranulocytosis, skin rashes, and arthralgias. Both drugs may also result in more benign ADRs like gastrointestinal upset and headaches and must be used cautiously during pregnancy due to potential risks to the fetus.
Step-by-step explanation:
The ADRs (Adverse Drug Reactions) of PTU (Propylthiouracil) and Methimazole are particularly relevant in treating thyroid conditions such as hyperthyroidism, where they act to inhibit thyroid hormone synthesis. However, they can lead to several side effects. For PTU, ADRs include hepatotoxicity, which can be severe enough to warrant a liver transplant, and antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis. Common ADRs associated with Methimazole include agranulocytosis, which is a potentially life-threatening decrease in the number of white blood cells, skin rashes, and arthralgias.
Both drugs can cause cutaneous reactions and, in rare cases, can lead to vasculitis. It is important to monitor patients closely for the development of these ADRs. More benign ADRs like gastrointestinal upset and headache may also occur with both medications. Lastly, since PTU and Methimazole can cross the placental barrier, they must be used cautiously during pregnancy due to the risk of developing fetal goiter and hypothyroidism.