Final answer:
Goodell's sign refers to the softening of the cervix, which is a probable sign of pregnancy, commonly observed around the fourth or fifth week of gestation.
Step-by-step explanation:
Goodell's sign is a physiological change seen in pregnancy, generally considered to be a probable sign of pregnancy. It is characterized by a significant softening of the cervix, which typically becomes more pliant and softer to the touch. This change is believed to be due to increased vascular congestion, edema, and increased estrogen levels associated with pregnancy. Goodell's sign can be observed as early as the fourth or fifth week of gestation, and is assessed during a pelvic examination.
Although Goodell's sign is an important indicator, it should be corroborated with other signs and symptoms of pregnancy, as well as pregnancy tests for a definitive diagnosis. This is due to the fact that Goodell's sign could potentially be mimicked by other medical conditions unrelated to pregnancy.