Final answer:
First-line treatment for uncomplicated CAP with acute onset typically involves macrolides, with azithromycin being a common choice. Alternatives may include fluoroquinolones like levofloxacin or ß-Lactam antibiotics such as amoxicillin if resistance is not a concern.
Step-by-step explanation:
The first-line treatment for uncomplicated community-acquired pneumonia (CAP) with acute onset is typically a class of antibiotics known as macrolides, with azithromycin being a common choice. Alternatives include fluoroquinolones, like levofloxacin, especially when there's a concern for ß-Lactam resistance. When ß-Lactam resistance is not a concern, ß-Lactam antibiotics such as amoxicillin might be used.
However, due to resistance issues, if ß-Lactam antibiotics prove ineffective, macrolides or fluoroquinolones may be prescribed. It's also important to note that pneumococcal vaccines such as PCV13 and PPSV23 are essential in preventing S. pneumoniae infections, which are a common cause of CAP.