Final answer:
Long-term use of PPI in postmenopausal women increases the risk of stroke, heart attack, blood clots, breast cancer, ovarian cancer, endometrial cancer, gall bladder disease, and possibly dementia.
Step-by-step explanation:
Prolonged use of proton-pump inhibitors (PPIs) in postmenopausal women has been associated with an increased risk of various negative side effects. These include an increased risk of stroke or heart attack, blood clots, breast cancer, ovarian cancer, endometrial cancer, gall bladder disease, and possibly dementia.
It is important for postmenopausal women to be aware of these potential risks and discuss them with their healthcare provider before continuing long-term PPI use.