Final answer:
Adult-onset Still's disease typically presents with high spiking fevers, a distinctive salmon-colored rash, arthritis with joint pain and swelling, and muscle pain. Additional systemic symptoms may include lymphadenopathy, hepatomegaly, and splenomegaly. The disease course is unpredictable with inflammatory markers often elevated.
Step-by-step explanation:
The clinical features and manifestations commonly associated with adult-onset Still's disease include a constellation of symptoms. Patients often present with a high spiking fever, typically 39-40°C (102-104°F), that tends to occur in the late afternoon or early evening. Accompanying the fever is a distinctive salmon-colored rash that usually appears during febrile episodes and might be itchy or painful.
Besides these hallmark features, other common symptoms include sore throat, arthritis with joint pain and swelling that can be debilitating, and muscle pain. Some patients may also exhibit systemic symptoms such as weight loss, lymphadenopathy (swollen lymph nodes), hepatomegaly (enlarged liver), and splenomegaly (enlarged spleen). Additionally, serositis, which is inflammation of the lining of organs like the heart and lungs, can lead to complications such as pericarditis and pleuritis.
It is also important to note that the clinical course of adult-onset Still's disease can be unpredictable, with patients experiencing episodes of symptoms (flares) followed by periods of remission. Blood tests in patients with Still's disease often show elevated markers of inflammation such as high levels of C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR). Ultimately, thorough clinical evaluation and diagnostic tests are required to confirm the diagnosis, as the symptoms can mimic other conditions.