Final answer:
The first-line therapy for gout is uricosuric drugs. However, there are contraindications for their use.
Step-by-step explanation:
The first-line therapy for gout is usually uricosuric drugs like salicylates, cinchopher, and adrenal cortical hormones. These drugs increase the excretion of uric acid in the urine by decreasing its re-absorption. However, there are contraindications for their use. For example, salicylates are contraindicated in people with bleeding disorders or gastric ulcers, adrenal cortical hormones are contraindicated in people with systemic fungal infections, and cinchopher is contraindicated in people with hypersensitivity to it.