Final answer:
If traditional pain medications do not relieve pain associated with vertebral compression fractures 2/2 osteoporosis, alternative strategies such as non-opioid medications or interventional procedures can be considered.
Step-by-step explanation:
If a patient with a vertebral compression fracture 2/2 osteoporosis has pain that is refractory to NSAIDs, acetaminophen, and opioids, there are alternative pain management strategies that can be considered. One option is the use of non-opioid medications such as antidepressants or anticonvulsants, which can help alleviate nerve-related pain. Another option is the use of interventional procedures such as vertebroplasty or kyphoplasty, which involve injecting cement into the fractured vertebra to stabilize it and relieve pain.