Question

Which of the following best explains the chain of events that occurs when glucagon binds to its receptor?

a) activation of protein kinase A, activation of G protein, activation of adenylate cyclase, production of cAMP

b) activation of adenylate cyclase, production of cAMP, activation of protein kinase A, activation of G protein

c) production of cAMP, activation of adenylate cyclase, activation of protein kinase A, activation of G protein

d) activation of G protein, activation of protein kinase A, activation of adenylate cyclase, production of cAMP

e) activation of G protein, activation of adenylate cyclase, production of cAMP, activation of protein kinase A

Answer 1

The chain of events when glucagon binds to its receptor involves the activation of the G protein, adenylate cyclase, production of cAMP, and protein kinase A. This pathway triggers a phosphorylation cascade and various cellular responses.

Step-by-step explanation:

The chain of events that occurs when glucagon binds to its receptor can be best explained by the following sequence:

1. Activation of G protein
2. Activation of adenylate cyclase
3. Production of cAMP
4. Activation of protein kinase A

Glucagon binds to its receptor on the cell membrane, which activates the G protein. The activated G protein then activates adenylate cyclase, an enzyme that converts ATP to cyclic AMP (cAMP). The production of cAMP activates protein kinase A (PKA), which initiates a phosphorylation cascade that results in various cellular responses.