Final answer:
The relative reactivities of acyl compounds towards nucleophilic substitution are in the order of Acyl chloride > Ester > Acid anhydride > Amide. In nucleophilic acyl substitution reactions, the reactivity of acyl compounds depends on the leaving group ability of the functional group attached to the carbonyl carbon.
Step-by-step explanation:
The relative reactivities of acyl compounds towards nucleophilic substitution are in the order of:
- Acyl chloride > Ester > Acid anhydride > Amide
In nucleophilic acyl substitution reactions, the reactivity of acyl compounds depends on the leaving group ability of the functional group attached to the carbonyl carbon. Acyl chlorides have the highest reactivity due to the chlorine leaving group, while amides have the lowest reactivity because the amine group is a poor leaving group. The order of reactivity determines the ease of conversion from one acyl compound to another.