Question

Which of the following are the reason(s) for Rheumatoid arthritis? Choose the correct option.

i.The ability to differentiate pathogens or foreign molecules from self cells increases

ii.Body attacks self cells

iii.More antibodies are produced in the body

iv.The ability to differentiate pathogens or foreign molecules from self cells is lost


A.ii and iv
B.i and ii
C.i and iii
D.iii and iv

Answer 1

The reasons for Rheumatoid arthritis include the body attacking self cells and the loss of the ability to differentiate between pathogens or foreign molecules and self cells, making the correct answer A. ii and iv.

Step-by-step explanation:

Rheumatoid arthritis (RA) is an autoimmune disease in which the body's immune system mistakenly attacks healthy tissue, particularly the synovial joints, leading to inflammation and pain. The reasons for rheumatoid arthritis include the body attacking self cells (autoimmunity) and the loss of the ability to differentiate pathogens or foreign molecules from self cells. Thus, the correct options are:

• ii. Body attacks self cells
• iv. The ability to differentiate pathogens or foreign molecules from self cells is lost

In the case of RA, the activated immune system, including CD4 T cells, leads to the chronic release of inflammatory cytokines and the production of autoantibodies such as rheumatoid factor (RF) and anti-citrullinated protein antibodies (ACPAs), which contribute to joint damage.

The correct answer to the question "Which of the following are the reason(s) for Rheumatoid arthritis?" is:

A. ii and iv