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A normal protein has the amino acid sequence: tryp- gln - val - ser - leu

A mutation occurred in the DNA. The amino acid sequence that resulted from this
changed gene is: tryp- gln - ile - ser - leu
What type of mutation occurred in the protein?

User Samith
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1 Answer

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Final answer:

A 'missense mutation' resulted in the substitution of isoleucine for valine in the protein sequence, changing the normally encoded amino acid to a different one.

Step-by-step explanation:

The mutation in the protein sequence described is a missense mutation. In this particular case, the normal amino acid sequence 'tryp-gln-val-ser-leu' has been altered to 'tryp-gln-ile-ser-leu'. The valine (val) has been replaced by isoleucine (ile).

Missense mutations occur when a single nucleotide change in a DNA sequence leads to the substitution of one amino acid for another in the protein produced.

An example of the impact of such a mutation is seen in sickle cell anemia, where the amino acid glutamic acid is replaced by valine, leading to dramatic changes in the shape and function of red blood cells.

User Mihuilk
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