Final answer:
The major issue edited out of the original Declaration of Independence was slavery and the slave trade.
Step-by-step explanation:
The major issue in America that was edited out of the original Declaration of Independence was (a) Slavery and the slave trade.
The Declaration of Independence was initially drafted by Thomas Jefferson and the committee of five, which included John Adams, Benjamin Franklin, Robert Sherman, and Robert R. Livingston. However, they had to remove the section that addressed slavery to gain support from the Southern colonies, who heavily relied on slave labor.
This omission became a contentious issue in American history and contributed to the divide between Northern and Southern states, eventually leading to the Civil War.