Final answer:
The Trail of Tears is the event where Cherokee Indians were forcibly removed to Oklahoma following the Indian Removal Act of 1830, resulting in thousands of deaths.
Step-by-step explanation:
The major event in history where the Cherokee Indians were removed from their homes and pushed towards Oklahoma is known as the Trail of Tears. This tragic episode followed the passage of the Indian Removal Act in 1830, which was signed by President Andrew Jackson. The U.S. military forcibly moved the Cherokee, as well as other tribes such as the Chickasaw, Choctaw, Creek, and Seminole, from the Southeast to an area in the western territory, now known as Oklahoma. As the Cherokee were forced to leave their ancestral lands, thousands died during the harsh journey due to exposure, disease, and starvation.