Final answer:
A perimenopausal woman with irregular bleeding, bloating, endometrial hyperplasia, and an adnexal mass may have endometrial or ovarian cancer. Hormonal changes contribute to these symptoms and medical evaluation is required.
Step-by-step explanation:
A perimenopausal woman experiencing acute onset of irregular vaginal bleeding, abdominal bloating, endometrial hyperplasia, and a large adnexal mass may be exhibiting symptoms of several conditions, including endometrial cancer. The hormonal changes during perimenopause, characterized by reduced progesterone levels and near-normal estrogen levels, can lead to the abnormal growth of the endometrium, enhancing the risk of cancer. Additionally, the presence of a large adnexal mass is concerning and can also indicate ovarian cancer or large uterine fibroids, which are generally benign. A full medical evaluation including biopsy, imaging studies, and perhaps surgical intervention may be required to establish a diagnosis and appropriate treatment plan.