Final answer:
Acanthosis Nigricans is associated with insulin resistance and can be an indicator of serious health conditions including severe diabetes mellitus and genetic disorders such as Donohue syndrome and Rabson-Mendenhall syndrome.
Step-by-step explanation:
Acanthosis Nigricans is commonly associated with conditions of insulin resistance. This skin condition is characterized by darkened and thickened patches of skin that often occur in body folds. It is a marker that can indicate serious health issues such as severe diabetes mellitus and is also seen in some genetic disorders.
In particular, patients with homozygous mutations in the INSR gene that cause Donohue syndrome or Leprechaunism and Rabson-Mendenhall syndrome, exhibit Acanthosis Nigricans. Unfortunately, Donohue syndrome is often fatal within the first year of life due to non-functional insulin receptors. Rabson-Mendenhall syndrome presents with abnormal glucose level fluctuations and additional symptoms such as abnormal teeth and hypertrophic gums.