Question

What would you use to confirm/workup a suspected *Antiphospholipid syndrome* in a patient with a hx of recurrent 1st trimester miscarriages?

How do you treat this?

Answer 1

To confirm Antiphospholipid syndrome, additional tests such as aCL, anti-β2GPI, and LA tests should be performed. Treatment may involve anticoagulant medications and aspirin combined with low-dose heparin.

Step-by-step explanation:

To confirm a suspected Antiphospholipid syndrome in a patient with a history of recurrent 1st trimester miscarriages, the doctor should perform the following additional tests:

1. Anticardiolipin antibodies (aCL) test
2. Anti-beta2-glycoprotein I antibodies (anti-β2GPI) test
3. Lupus anticoagulant (LA) test

These tests help detect the presence of specific antibodies associated with Antiphospholipid syndrome in the patient's blood.

The treatment for Antiphospholipid syndrome involves:

• For prevention of blood clots: Anticoagulant medications like heparin or warfarin
• For patients with recurrent miscarriages: Aspirin combined with low-dose heparin